Pregnyl 5000 IU (Human Chorionic Gonadotropin)

Pregnyl 5000 IU is a potent, injectable hormonal medication containing Human Chorionic Gonadotropin (hCG). Manufactured by Organon, this 5000 IU dosage is a critical prescription therapy with distinct uses for both women and men.

It is medically prescribed to treat female infertility by inducing ovulation and to treat male hypogonadism. It is also widely used “off-label” by men as part of a Post-Cycle Therapy (PCT) protocol to restore testicular function.

Product Overview: Pregnyl 5000 IU (hCG)

Pregnyl 5000 IU is not a steroid; it is a complex glycoprotein hormone. The active ingredient, hCG, is structurally very similar to Luteinizing Hormone (LH). Because of this similarity, Pregnyl can mimic the action of LH in the body.

This product is supplied as a lyophilized (freeze-dried) powder that must be “reconstituted” (mixed) with the provided sterile solvent before it can be injected.

How Does Pregnyl 5000 IU (hCG) Work?

The mechanism of action depends on the patient:

• In Women (Fertility): In fertility treatments, Pregnyl is used as a “trigger shot.” After a course of follicle-stimulating hormones, a large dose of Pregnyl is administered to mimic the natural mid-cycle LH surge. This powerful signal forces the mature follicles in the ovaries to rupture and release their eggs (ovulation).
• In Men (Hypogonadism & PCT): In the male body, Luteinizing Hormone (LH) is the primary signal sent from the pituitary gland to the testes (Leydig cells), instructing them to produce testosterone. By mimicking LH, Pregnyl 5000 IU directly stimulates the testes, “restarting” or increasing natural testosterone production and restoring testicular volume.

Key Product Details

Dosage and Administration

Pregnyl 5000 IU must be prepared (reconstituted) before use.

1. Reconstitution: The 5000 IU powder must be dissolved by adding the entire contents of the provided solvent (diluent) ampoule. Mix gently; do not shake. 2. Administration: The solution is then drawn into a syringe and administered as either an intramuscular (IM) or subcutaneous (sub-Q) injection.

Dosage protocols vary drastically:

• For Female Ovulation: Often a single, large injection of 5,000 to 10,000 IU.
• For Male Hypogonadism/PCT: Doses are much smaller and more frequent (e.g., 500 – 1000 IU two to three times per week).

Important: This is a prescription-only medication. You must follow the exact instructions for mixing, storing, and injecting provided by your healthcare provider.

Frequently Asked Questions (FAQ) about Pregnyl 5000 IU

How do I store Pregnyl after I have mixed it?

Before mixing, the vials can be stored at room temperature. After reconstitution (mixing the powder and liquid), the solution is no longer stable and must be stored in a refrigerator (between 2°C and 8°C). It typically must be used within 30-60 days.

What is the difference between hCG (Pregnyl) and SERMs (like Klomen or Tamoxifen)?

They work at different points in the hormonal axis.

• hCG (Pregnyl): Works directly on the testes (mimics LH) to produce testosterone.
• SERMs (Klomen/Tamoxifen): Work on the pituitary gland in the brain, blocking estrogen’s negative feedback to help the body produce its own LH.

Is Pregnyl (hCG) a steroid?

No. It is a peptide hormone, not an anabolic-androgenic steroid (AAS). It is used to counteract the side effects of steroids.

Can men get side effects from hCG?

Yes. By stimulating the testes to produce more testosterone, hCG can also increase the conversion of that testosterone into estrogen. This means it can potentially cause or worsen estrogenic side effects (like gynecomastia or water retention) if not used carefully, often in conjunction with an aromatase inhibitor.

Important Safety Information

Warning: Pregnyl is a potent hormone and must be used under strict medical supervision.

For Women: When used for fertility, hCG carries a risk of Ovarian Hyperstimulation Syndrome (OHSS), a rare but serious condition. For Men: Do not use Pregnyl if you have a history of prostate cancer or certain other hormone-sensitive cancers.

Do not take Pregnyl if you are allergic to hCG or if you are pregnant (unless specifically used as a “trigger shot” in a fertility protocol).

Disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice. PregnHyl (hCG) is a prescription medication. Always consult with your fertility specialist, endocrinologist, or qualified healthcare provider.